摘要
目的:探讨先天性心脏病(简称先心,CHD)肺动脉高压(PH)患儿血浆肾上腺髓质素(ADM)与肺动脉压力的关系。方法:CHD患儿40例,按其心导管检查或先心修补术中测得肺动脉压力分为中重度肺高压组(肺动脉收缩压>50mmHg,n=12)、轻度肺高压组(肺动脉收缩压30～50mmHg,n=14)和CHD无肺高压组(肺动脉收缩压<30mmHg,n=14),选取无心肝肾疾患健康儿童作为对照组(n=10);分别采肺动脉血3ml,抗凝离心后收集血浆,酶联免疫法测血浆ADM浓度。结果:血浆ADM浓度呈上升趋势,与对照组比较,CHD各组血浆ADM浓度显著升高(P<0.01);轻度PH组、中重度PH组与无PH组比较血浆ADM浓度显著升高(P<0.01);中重度PH组与轻度PH组比较血浆ADM浓度显著升高(P<0.01)。相关分析显示:ADM浓度与肺收缩压呈显著正相关(r=0.939,P<0.01);直线回归方程为Y=7.371+0.997X(X:肺动脉压力,Y:ADM浓度)。结论:ADM参于了先心肺高压的病理生理过程,随着肺动脉压力升高,血浆ADM浓度逐步升高,延缓肺高压的发生、发展,是机体的防御反应。
Objective: To explore the relation between the concentration of plasma adrenomedulin(ADM) and pulmonary pressure in children with pulmonary hypertension(PH) secondary to congenital heart disease(CHD). Methods: Forty patients with CHD were divided into three groups according to the pulmonary pressure measured in cardiac catheterization and surgery: normal pulmonary pressure group(n=14),mild PH group(n=14),severe or moderate PH group (n=12), and the control group(n=10) were enrolled in the study. The concentrations of plasm ADM were assayed with euzymelinked immunosorbent assay. Results: The concentrations of plasm ADM increased along with pulmonary pressure stepped up,there was significant difference between any two of normal pulmonary pressure group,mild PH group,severe or moderate PH group and the control group(P<0.01). There was a significant positive correlation between the concentrations of ADM and pulmonary pressure(r=0.939,P<0.01),the linear regression equation was Y=7.371+0.997X (X:pulmonary pressure,Y:the concentrations of ADM). Conclusion: ADM takes part in the pathogen- esis of PH secondary to CHD,the concentrations of plasm ADM escalate along with pulmonary pressure stepped up,can delay the process of pulmonary hypertension.
出处
《温州医学院学报》
CAS
2005年第3期195-197,共3页
Journal of Wenzhou Medical College
关键词
先天性心脏病
肺动脉高压
肾上腺髓质素
congenital heart diseases
pulmonary hypertension
adrenomedulin
