摘要
我们报道人粒细胞白血病（ＨＬ６０）裸鼠异种移植瘤的建立及其生物学特性，该移植瘤已在裸鼠间连续传代２０余代，成功率达１００％。移植瘤瘤细胞表面抗原为稳定的粒细胞标记。利用该模型进行了单克隆抗体柔红霉素偶合物的导向治疗，结果显示对肿瘤生长有明显抑制作用。为在体内条件下对人类白血病进行研究和实验性治疗提供了良好的工具。
his paper dealt with the establishment and biologicalcharacteristics of human myelocytic leukemia(HL-60)xenografted in nude mice.The xenograft tumors havebeen propagated for over 20 generations in BALB/c nudemice.The take rate was over 90%.Myeloid cell surfaceantigens were stably expressed on the tumor cells.Tar-get therapy of McAb-DNR conjugate was performed innude mice bearing tumors.The results demonstratedthat McAb-DNR conjugate remarkably inhibited the tu-mor growth.This study provided an important tool forstudy and experiment therapy of human leukemia in vi-vo.
出处
《中华血液学杂志》
CSCD
北大核心
1994年第5期239-241,共3页
Chinese Journal of Hematology
基金
国家"七.五"攻关课题
关键词
异种移植瘤
白血病
导向疗法
Xenograft tumor Nude mice Hu-man leukemia Target therapy
