摘要
目的:通过检测原癌基因c met、表皮生长因子(EGF)和EGF受体(EGFR)在正常外阴皮肤,外阴上皮内瘤变(VIN)和外阴鳞状细胞癌(VSCC)中的表达,探讨其在外阴癌变中的作用。方法:应用免疫组化SABC法进行检测。c met,EGF和EGFR的表达与外阴肿瘤的临床病理特征相比较。结果:c met在80%VSCC和20%VINⅢ中表达(P<0.05)。EGF在100%VSCC和VINⅢ以及20%VINI,Ⅱ中表达。EGFR在67%VSCC和40%的VINⅢ中表达(P<0.05)。c met更强表达于高分化型的VSCC中,与中/低分化型差异显著(P<0.05)。结论:EGF,c met是外阴癌变的早期事件。
Objective: To study the role of oncogene c-met, epidermal growth factor (EGF), and EGF receptor (EGFR) in vulvar carcinogenesis by determining the expressions in vulvar intraepithelial neoplasia (VIN) and vulvar squamous cell carcinomas(VSCC). Methods: The immunohistochemistry SABC method was used. The expressions of c-met, EGF, and EGFR were analyzed with clinical-pathologic features of vulvar tumors. Results: The c-met expressed in 80% of VSCC and 20% of VINⅢ. The EGF expressed in 100% of VSCC and VIN stage Ⅲ, and 20% of VIN stage Ⅰ, Ⅱ. The EGFR expressed in 67% of VSCC and 40% of VIN stage Ⅲ. The expression of VIN stage Ⅲ and VSCC was different (P<0.05). The c-met expressed more intensely in well differentiated VSCC than that in moderately and poorly differentiated VSCC (P<0.05). Conclusion: The c-met and EGF expression may be an early event in malignant transformation of vulvar squamous cells. Over-expression of c-met, EGF, and EGFR correlated with malignant transformation of vulvar squamous cells.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2005年第3期235-236,共2页
Journal of China Medical University
基金
辽宁省科技厅科研基金资助项目(200122500215)
