摘要
睾丸决定因子（Ｔｅｓｔｉｓ－ｄｅｔｅｒｍｉｎｉｎｇｆａｃｔｏｒ，ＴＤＦ）位于Ｙ染色体短臂上，它的表达产物诱导睾丸组织的发生。ＳＲＹ基因（Ｓｅｘ－ｄｅｔｅｒｍｉｎｉｎｇｒｅｇｉｏｎｏｆｔｈｅＹ）位于Ｙ染色体的性别决定区内，许多特征显示ＳＲＹ可能就是ＴＤＦ。采用多聚酶链反应（ＰＣＲ）结合斑点杂交对３例４６，ＸＸ真两性畸形性腺组织的石蜡切片中ＳＲＹ基因进行检测，２例检测到ＳＲＹ基因，１例未检测到。性腺组织病理检查均为卵睾组织。为探讨两性畸形的发病机理提供了资料。
The testis-determining factor(TDF) lies on the Y chromosone and is responsible for initiating mate determination.SRY is a gene located in the sex determining region of the human Y chromosone and has many of the properties expected of TDF. Using polymerase chain reaction (PCR) and dot blot on paraffin-embedded gonad tissue taken from 46, XX true hermaphrodites,the SRY gene was detected in two out of three cases but not in the third. All three gonads were ovariotestis on pathological examination. The results contributed to the understanding of the mechanism of 46,XX true hermaphroditism.
出处
《中华小儿外科杂志》
CSCD
1994年第5期262-263,共2页
Chinese Journal of Pediatric Surgery
基金
北京市自然科学基金
