摘要
用放射免疫法检测６１例男性慢性肝病患者血清睾酮（Ｔ）、雌二醇（Ｅ２）、泌乳素（ＰＲＬ）、促黄体生成素（ＬＨ）和卵泡刺激素（ＦＳＨ）的浓度，并对部分病例进行促黄体生成素释放激素（ＬＲＨ）垂体兴奋试验和绒毛膜促性腺激素（ＨＣＧ）刺激试验。结果示，肝硬化基础血清Ｔ显著降低（Ｐ＜０．０１）；对ＬＲＨ垂体兴奋试验ＬＨ多数呈正常反应，部分呈延迟反应或低反应；而对ＨＣＧ刺激试验均呈正常反应。提示肝硬化患者有下丘脑－垂体－性腺轴功能障碍。
In the present study,serum concentrations of
testosterone(T),estradiol(E2),prolactin(PRL),luteinizing hormone(LH)and follicule-stimulating
hormone(FSH)were measured in 6l men withchronic liver disease using RIA. Some of them
underwent luteinizing hormone releasinghormone(LRH) pituitary exciting test and chorionic
gonadotropin(HCG)stimulating test.Theresults showed that in patients with posthepatic
cirrhosis,serum concentrations of T Weresignificantly decreased (P<0.01),those of E2 normal
or decreased,and those of LH and FSH werenormal.The HCG stimutation test showed a normal
response.To LRH pituitary exciting test,mostof the patients expressed a normal response,but
some showed a delayed or low response.Theresults suggest that there is
hypothalamic-pituitary-gonadal dysfunction in the patients withcirrhosis mainly at the level of
hypothalamus. In a few patients,the dysfunction maybe at bothhypothalamus and pituitary.
Hypoorchidia is secondary.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1994年第6期336-338,共3页
Chinese Journal of Digestion
关键词
肝疾病
睾酮
雌二醇
泌乳素
促黄体生成素
男性
Poothepatic cirrhosis
Chronic hepatitis
Sex
hormones
Pituitarygonadotropic hormone
Prolactin.
