摘要
实验用雄性ＢＡＬＢ／Ｃ小鼠３０只，随机分６组，每隔４小时一组，用体视学方法分析各组间肝细胞超微结构的改变．结果提示肝细胞线粒体的功能在０４：００最强，在１２：００最弱；粗面内质网在０４：００和１２：００功能较强；糖原颗粒在夜间合成积累增多，白天消耗减少，脂滴形态改变的周期约１２小时。１２：００前后是肝细胞自我更新的重要时期．由此证实，肝细胞的线粒体、粗面内质网、糖原颗粒及脂滴的形态学都有显著的昼夜节律变化．
Thirty male BALB/C mice were randomly divided into six groups.One group was examined every 4-hour interval.Chronomorphological variations on mice hepatocytes were analysed by the method ofstereology.The results show that the function of mitochondria is the strongest at 04:00 h and the weakest at 12:00 h The function of rough edoplasmic reticulum is stronpr at 04:00 h and 12:00 h.The glycogen granules are composed in night and depleted in daytime.The rhythm of morphological variations in lipid droplets is about 12 hours.The study also indicates that aroud the 12:00 h is important period for hepatocytes to renew themselves.All the results suggest that the morphology of the mitochondria, rough endoplasmic reticulum,glycogen granules and lipid droplets are subject to strong circadian rhythm variations.
出处
《中华物理医学杂志》
CAS
CSCD
1994年第2期65-68,共4页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
小鼠
肝细胞
体视学
超微结构
mouse(BALB/C)
hepatocyte
stereology
chronomorphology
ultrastructure
