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38例轮状病毒肾损害的临床回顾性分析 被引量:10

Retrospective study for rotavirus renal damage
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摘要 目的 探讨轮状病毒(RV)肾损害的发生概况及预后。方法 对38 例入院时均解黄色水样便,大便培养阴性,轮状病毒检测阳性的患儿进行治疗前后尿常规,血、尿β2 -微球蛋白(β2 -MG)和血尿素氮及肌酐的检查。结果 38例患儿中共11例出现尿常规异常,占28%,血清β2-MG升高者8例(21%),尿中β2-MG升高者6例(16%),两者同时升高者2例(5%)。血尿素氮及肌酐检查正常。抗链球菌溶血素O均为阴性。该11 例尿常规出现异常的患儿,RV肠炎治愈后复查尿常规、血和尿β2-MG均恢复正常。结论 RV可以造成的肾脏损害,临床上短期预后良好。 Objective To discuss general situation and prognosis of rotavirus renal damage.Methods In thirty-eight patients with acute diarrhea, stool culture negative and rotavirus positive routine urnonocopy,levels of serum β_2-MG and β_2-MG in urine,ureanitrogen and creatinine were tested before and after treatment.Results 11 cases were abnormal by routine uronoscopy in 38 patients ,accounting for 28%, the serum β_2-MG increased levels in 8 cases (21%),The levels of β_2-MG in urine were increased in 6 patients (16%),both increased in 2 cases(5%).The urea nitrogen and creatinine were normal.11 patients with abnormity of routine uronoscopy resumed normal after cured rotavirus enteritis.Conclusion Renal damage of rotavirus mostly manifested simple proteinuria.Rotavirus renal damage has a favourable prognosis.
作者 陈一丹 许煊
出处 《临床医学》 CAS 2005年第5期7-8,共2页 Clinical Medicine
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参考文献2

  • 1Gilger MA,Matson DO,Conner ME,et al.Extraintestinal rotavirus infections in children with immunodeficiency.J Pediatr,1992,120(6):912.
  • 2Ciarlet M, Crawford SE, Cheng E, et al. VLA-2(alpha2 betal) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment.J Virol,2002,76(3):1109.

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