摘要
我们以培养的正常人黑素细胞为特异性抗原研究了白癜风患者淋巴细胞的增殖反应。结果２６例白癜风患者的特异性淋巴细胞转化试验，３Ｈ ＴｄＲ掺入平均ｃｐｍ值为２０３．４８±２８．９４，２２例健康对照组３Ｈ ＴｄＲ掺入平均ｃｐｍ值为９９．０３±１２．１５，显示患者淋巴细胞增殖反应明显高于正常者。经统计学分析两者差异有显著意义（Ｐ＝０．００３１）。而与性别、病程无相关关系。提示白癫风的发病与细胞免疫异常有关。
The proliferative responses of lymphocytes of vitiligo patients to cultured normal human melanocytes were studied. Lymphocyte transformation test with cultured normal melanocytes as specific antigen was performed in 26 vitiligo patients and 22 healthy individuals as control. It was found that the incorporation of 3HTdR in the vitiligo patients was 230.48 28.94 cpm, while 99.03 12.15 cpm in the controls. The results indicated that the patients with vitiligo had a signihcantly increased proliferative responses of lymphocytes to normal melanocytes in comparisons with the controls. The proliferative responses of lymphocytes showed no correlation with the sex or disease duration in the patients. The results suggest that aberrations in cell-mediated immunity may play a role in the pathogenesis of vitiligo.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1994年第1期6-9,共4页
Chinese Journal of Dermatology
基金
国家自然科学基金资助项目
关键词
白癜风
黑素细胞
淋巴细胞
转化
Vitiligo
Melanocyte
Lymphocyte transformation
