摘要
在不同肾功能状态的病人中，观察了口服单剂量环丙氟哌酸５００ｍｇ的药代动力学。结果表明，肾功能变化对其药代动力学参数有显著影响，药物经肾清除率和消除半衰期与肌酐清除率密切相关。在肾功能严重受损的病人中，服药量应根据药代动力学的变化减少为正常剂量的１／２，或服药时间间隔延长１倍。
he parmacokinetics of ciprofloxacin was investigated in 12 patients with renal function of various degrees.A single dose of 500mg of ciprofloxacin was administered after overnight fasting.Serum and urine samples were collected serially at different intervals and subjected to bioassay and HPLC.Pharmacokinetic parameters were analyzed by assuming an open two-compartment model.Apparent difference was observed in pharmacokinetic parameters between patients with severe impainnent of renal function and those with noimal renal function,For the former group,the area under the curve of serum concentration versus time was tripled(42.22 ± 12.48 vs. 14.55 ± 6.66mg·h￣(-1)· ml￣(-1),the renal clearance of ciprofloxacin was reduced to one-tenth(22.43 ± 12.08 vs.193.13 ± 65.14ml / min),and the elimination half-life was prolonged twofold(9.28 ± 2.42 vs.4.72 ±1.35h). The correlation between renal drug clearance and Ccr was highly significant(r=0.935, P<0.001). On the basis of these findings,it is suggested that a reduction of one half of the dose of ciprofioxacin or an increase of a double of the administration time interval may be indicated in chronic renal failure with GFR less than 25 ml / min.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1994年第7期449-451,共3页
Chinese Journal of Internal Medicine
关键词
环丙氟哌酸
肾疾病
药代动力学
Ciprofloxacin Kidney diseases Pharmacokinetics
