摘要
目的 比较培哚普利和氨酰心安对高血压患者微白蛋白尿的影响。方法 32例高血压病患者随机分为两组 ,分别服用培哚普利 (4mg/d)和氨酰心安 (5 0mg/d)各 2 4周 ,所获数据用方差分析 ,求P值用t检验。结果 两类药物降低动脉血压的程度相同 ,培哚普利治疗使微白蛋白尿显著减少 ,而氨酰心安对微白蛋白尿无明显影响 (P <0 .0 1)。结论 培哚普利降低白蛋白尿作用不依赖于动脉血压的有效降低 。
Objective The effects of perinodpril and atenolol on microalbuminura were investigated in 24 patients with essential hypertension. Methods The patients were divided randomly into two groups received respectively 4mg perinodpril daily and 50mg atenolol daily for 24 weeks.Results The blood pressure decreased in a similar way in both groups. Microalbuminuria decreased significently in patients receiving perinodpril (P<0.01). No significant changes were observed with atenolol. Conclusion It is probable that the positive effects of perinodpril reduce urinary excretion of microabluminis attributable to the modifications in intrarenal circulation or to a change in glomerular permeability.
出处
《菏泽医学专科学校学报》
2001年第3期42-43,共2页
Journal of Heze Medical College
