摘要
目的 :观察电刺激家兔嗅区黏膜记录的诱发电位的波形及其稳定性 ,探讨一种可以客观评价嗅觉功能的方法。方法 :将双极刺激电极经家兔前鼻孔置于嗅区黏膜 ,给予电刺激 ,在颅顶记录嗅觉诱发电位 (OEPs) ;改变刺激参数和部位 ,观察对电位潜伏期、阈值和波形的影响。结果 :在颅顶前方近嗅球处记录到一组波形稳定的N1 P1 N2 3相复合波 ,潜伏期为 :N1波 2 0 .6ms ,P1波 33.5ms ,N2 波 5 8.3ms;改变刺激强度对各波无明显影响 ;改变刺激频率对各波影响较大 ,频率过高 ,波形分化较差。结论 :正常OEPs是一组波形稳定的负 正 负 3相复合波 ,波形稳定、重复性好 ,各参量可作为评价嗅觉功能变化的有用指标。
Objective:To observe olfactory evoked potential(OEPs) produced by electrical stimulation of the olfactory mucosa and to find out an objective way to appraise olfactory function.Method:A bipolar stimulus electrode was placed on the olfactory mucosa of adult health rabbits via anterior naris. Olfactory evoked potential was recorded at headtop after being given a 0.5 ～ 4.0 mA current to the mucosa. And we also investigated the effect of stimulus parameters and stimulus location to the wave form of OEPs.Result:Triphasic negative positive negative evoked potentials were recorded from the surface of the frontal head close to olfactory bulb. Latent period of three waves respectively was N 1 20.6 ms, P 1 33.5 ms, N 2 58.3 ms.Conclusion:In general, the OEPs were composed of triphasic negative positive negative complexes. The waveforms were stable and could be repeated well. Each parameter was useful for estimating the olfactory function.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2003年第10期618-620,共3页
Journal of Clinical Otorhinolaryngology
基金
国家自然科学基金资助项目 (No .396 70 780 )
北京市自然科学基金资助项目 (No .7992 0 15 )
关键词
嗅觉
诱发电位
嗅黏膜
Olfactory
Evoked potential
Olfactory mucosa
