摘要
目的探讨不同光暗周期对小鼠白细胞数量分类计数与自发运动活动的影响。方法144只小鼠分3组,置于14h、24h及32h光暗周期条件下,第8周眼眶取血,行外周血白细胞计数及分类计数。另9只小鼠亦采用上述光暗周期,分成3组,连续监测小鼠的自发运动活动。结果小鼠自发运动活动周期与光暗循环周期一致;不同光暗周期对小鼠外周血白细胞计数及分类计数有不同影响。结论不同光暗周期不仅影响小鼠自发运动活动,而且影响其白细胞计数及分类计数,提示不同光暗周期对机体免疫可能产生不同的作用。
Objective To investigate the effect of different light-dark cycles on total and differential counts of leukocyte as well as spontaneous locomotor activity in mice. Method 144 ICR mice were raised under different light-dark cycles including LD 7 h/ 7 h ,LD 12 h/12 h and LD 16 h/16 h for 8 weeks. Blood samples were obtained by enucleation of eye for total and differential counts of leukocyte. Another 9 mice were also divided into 3 groups and fed under same conditions as above. Their activities were recorded continuously. Result The change of spontaneous locomotor activity and leukocyte count were synchronized with the light-dark cycle.Conclusion Different light-dark cycles can influence not only the spontaneous locomotor activity, but also total and differential leukocyte counts in mice.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2005年第3期219-221,共3页
Space Medicine & Medical Engineering
基金
国家自然科学基金(39970275
30070288)
关键词
光暗循环
白细胞
自发运动活动
时间生物学
light-dark cycle
leukocytes
spontaneous locosmotor activity
chronobiology
