摘要
先锋霉素类药物是广泛使用的抗菌药物，有过敏反应或与青霉素有交叉过敏现象。在工作中我们曾遇到过由于注射先锋霉素过敏致死的医疗纠纷案例。使用文献所报道的高效液相色谱方法和荧光法检案时发现．检血中加入不同沉淀剂离心后直接取样进行液相色谱分析，由于药浓稀释，不易检出而且不能准确定性。
In this paper,a method for separating and determinating eight cephalosporins are developed with CS-930 Dual-Wavelenth Thin-Layer Chromatograph scanner. The cephalosporins are confirmed by their Rf and UV bsorbed curves,The relative recovery of extracting cephalothin from blood with chloroform is about 90%.The linear scope of quantiting cephalothin is between 0.5 and 8.0ug. The stability of cephalothin in postmortem blood is also investigated.
出处
《法医学杂志》
CAS
CSCD
1990年第1期28-32,共5页
Journal of Forensic Medicine
