摘要
对恶性肿瘤７０例（恶性组）、良性肿瘤５０例（良性组）和正常健康妇女５０例（对照组）尿中半抗氨酸蛋白酶（ＵＣＰ）活性进行测定。结果：ＵＣＰ辅助诊断恶性肿瘤的敏感性为９０％、特异性为８０％、准确性为８６％。恶性组ＵＣＰ值明显高于良性组和对照组（Ｐ＜０．０１）。ＵＣＰ检测对卵巢癌尤为敏感，敏感性为９５％，高于子宫体癌（７７％）、宫颈癌（８５％）。ＵＣＰ、血清肿瘤标记物ＣＡ＿（１２５）及乳酸脱氢酶（ＬＤＨ）同功酶辅助诊断卵巢癌的敏感性依次为９０％、８５％、７５％；特异性为８０％、８７％、８５％；准确性为８４％、８４％、８０％。ＵＣＰ与ＣＡ＿（１２５）对卵巢癌的辅助诊断有同样的价值，而且优于ＬＤＨ同功酶。８例卵巢癌Ⅰ期患者，７例ＵＣＰ值异常，而同组６例卵巢癌Ⅰ期患者中，无１例ＣＡ＿（１２５）值异常，说明ＵＣＰ检测对早期卵巢癌较ＣＡ＿（１２５）更敏感。提示：ＵＣＰ可能成为妇科恶性肿瘤，特别是卵巢癌的标记物。
he levels of urine cystein protease (UCP) weredetected in the urines of 70 gynecological cancers, 50gynecological benign tumors and 50 normal women.The values of UCP assay of gynecological cancerswere much higher than those of benign and normalsamples (P <0.01). Best cut off point for diagnosis ofgynecological cancers was P_(95) and UCP cut off valuewas 0.24pmol . min￣(-1) /L by using percentile andROC curve. The sensitivity of UCP assay was 90%,specifity 80% and accuracy 86%. The sensitivity forovarian cancers was 95%, but 77% and 85% forcorpus and cervical cancers respectively. There wereno differences between UCP and CA_(125) (sensitivity85% , specifity 87% , accuracy 84%) in the diagnosis ofovarian cancers. In 7 cases of 8 cases of stage I ovariancancers, UCP were abnormal. In 6 cases of the samegroup, CA_(125) were normal ( < 35 000U / L). So UCPmay be better than CA_(125) in the diagnosis of earlyovarian cancer. The sensitivity of lactatedehydrogenase (LDH) isoenzyme was 75% in ovariancancer which was lower than UCP and CA_(125), but thespecifity 85% . LDH isoenzyme still was one of impor-tant tumor markers for diagnosis. Combined assayswith UCP, CA_(125) and LDH isoenzyme may reach thesensitivity 96% and specifity 100% evidently. Thesedata implied that UCP may be a good tumor markerin gynecological cancers especially for ovarian cancersin future.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1994年第2期85-87,123,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
半胱氨酸
蛋白酶
卵巢肿瘤
尿
Cysteine proteinase Ovarianneoplasms Tumor marker Lactatedehydrogenase isoenzymes
