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BRLF1-EBV的一种立即早期基因的研究进展 被引量：2

A Review Research Progress of BRLF1 One of EBV Immediate-Early Gene
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摘要 BRLF1是EBV的立即早期基因。作为一种反式激活因子,它可以调节EBV早期/晚期基因的表达,并且还可能参与裂解期病毒基因组的复制。它的表达与EBV潜伏周期向裂解周期的转换密切相关。BRLF1的蛋白产物Rta包含CTL识别的表位,可能在病毒裂解周期的早期成为免疫系统的作用位点。对它研究还可能为某些EBV相关肿瘤的筛查和治疗提供线索。
作者 任军 周玲 曾毅
机构地区 中国疾病预防与控制中心病毒病预防控制所
出处 《中国肿瘤》 CAS 2005年第6期372-375,共4页 China Cancer
关键词 Epstein—Barr病毒 BRLF1 RTA 基因
分类号 R73-3 [医药卫生—肿瘤]
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参考文献30

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同被引文献22

  • 1张玉,郜红艺,冯惠霞,邓玲,黄马燕,胡斌,程钢,吴秋良,崔念基,邵建永.鼻咽癌病人血浆和外周血白细胞EB病毒DNA定量分析[J].中华医学杂志,2004,84(12):982-986. 被引量：16
  • 2Wille CK, Nawandar DM, Panfil AR, et al. Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication. J Virol,2013 ,87 :935-950.
  • 3Cheng WM, Chan KH, Chen HL, et al. Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum. Int J Cancer, 2002,97:489 -492.
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  • 5Feng P, Cban SH, Soo MY, et al. Antibody response to Epstein- Barr virus Rta protein in patients with nasopharyngeal carcinoma:a new serologic parameter for diagnosis. Cancer, 2001, 92: 1872-1880.
  • 6Sener AG, Afsar I, Pinar E. Evaluation of Epstein-Barr virus antibodies, anti-VCA avidity by immunofluorescence and immunoblot assays for assessment of Epstein-Barr virus immunologic state. J Virol Methods, 2009,159:300-302.
  • 7E1-Guindy A, Ghiassi-Nejad M, et al. Essential role of Rta in lytic DNA replication of Epstein-Ban" virus[J]. J Virol, 2013, 87( 1 ) : 208-223.
  • 8Feng P, Chan SH, Soo MY, et al. Antibody response to Epstein- Ban" virus Rta protein in patients with nasopharyngeal carcinoma: a new serologic parameter for diagnosis [ J . Cancer, 2001,92 ( 7 ) : 1872-1879.
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  • 10Wille CK, Nawandar DM, Panfil AR, et al. Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1to activate Epstein-Ban" virus lytic gene expression and viral replication[J]. J Virol,2013,87(2) : 935-950.

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中国肿瘤
2005年 第6期

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