摘要
报告用卡介菌多糖核酸(BCG—PSN)防治哮喘反复发作60例。结果治愈68.3％,显效25.0％,有效6.7％。对照组显效24.4％,有效39.4％,无效36.4％,两组差异有非常显著意义。结果还显示;患儿IL-2水平明显低于正常儿童;内源性哮喘者T淋巴细胞集落形成单位(TL-CFU)明显低于正常儿童(P<0.01)。体外实验表明BCG-PSN能提高T细胞IL-2和IL-2R表达。这些结果提示哮喘患儿有细胞免疫功能不全,BCG-PSN有可能调整机体的免疫功能,具有防治哮喘反复发作的作用。
60 children with asthma were treated with BCG-PSN (1mg intramuscularly, twice a week for 3 months, and once a week for another 3 months) for preventing recurrent attacks. After 2-year follow-up, the results showed that the total effective rate was 100%: 41 cases cured, 15 significantly improved. 33 cases (control group) were treated with ketotifen (oral, 0.04mg/kg, bid for 3 months). The total effective rate was 63.6%, significant effects were obtained in 8 cases. T-lymphocyte colony forming units (TL-CFU), T cell subsets (CD3, CD4, CD8), interleukin-2 (TL-2) activity of PBL of 60 cases with asthma and 24 normal controls were determined. TL-CFU and IL-2 showed significant decrease. Number of TL-CFU and expression of IL-2R of T cells were enhanced by BCG-PSN in culture system. The present study suggested that there might be dysfunction of cellular immunity and the ability of T cells to proliferate and self-renew decreased in children with asthma and that BCG-PSN was able to restore the function of cellular immunity.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1994年第1期24-25,共2页
Chinese Journal of Pediatrics
