摘要
探讨不同休克条件下循环血中肿瘤坏死因子（ＴＮＦ）的动态变化规律及其可能的发生机制。实验发现内毒素休克时ＴＮＦ呈陡直的单峰曲线，持续时间较短（３～４小时）；绿脓杆菌败血症休克时ＴＮＦ呈平坦的单峰曲线，持续时间较长（６小时）；阑尾结扎穿孔（ＡＬＰ）感染性休克时ＴＮＦ呈前峰极低、后峰较高的双峰曲线，持续时间更长（１６小时）。结合不同剂量脂多糖（ＬＰＳ）在体外对肝Ｋｕｐｆｆｅｒ细胞释放ＴＮＦ的影响以及不同休克条件下血浆ＴＮＦ的变化特点，结果提示内毒素、绿脓杆菌败血症、ＡＬＰ感染性休克时循环血中ＴＮＦ不同动态变化特点可能主要取决于循环血中ＬＰＳ的不同浓度和不同持续时限。
he
rule of dynamic changes and mechanism of TNF in circulating blood in differential shock
models were investigated in thisstudy. It was found that the dynamic changes of circulating TNF
presented a single steep peak curve with shorter duration(about3-4h)in endotoxic shock.a
single smooth peak curve with longer duration(about 6h) in pseudomonas aeruginosa septic
shock,anda double peak curve with much longer duration(about 16h)in ALP septic
shock.According to the effect of different doses of LPSon TNF released by hepatic Kupffer cells
in vitro and the changes of plasma LPS during different shock conditions,the results sug-gested
that the rule of dynamic changes of circulating TNF during endotoxic,pseudomonas aeruginosa
sepsis. and ALP septic shock might mainly depend on the amount and duration of LPS in
circulating blood.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1994年第4期149-151,共3页
Chinese Journal of Trauma
基金
国家自然科学基金
关键词
休克
内毒素
感染
肿瘤坏死因子
Shock Endotoxic sepsis Tumor necrosis factor Lipopolysaccharide
