摘要
以自制的超临界反溶剂过程实验装置制备了乙基纤维素超细微粒。实验以乙醇为有机溶剂,超临界CO2为反溶剂,研究了操作温度、压力、反溶剂流量及溶液浓度等操作参数对制备的超细微粒的形态、粒径及粒径分布的影响。实验发现,通过控制实验参数,可使制备的乙基纤维素微粒基本呈球形,最小粒径可降至1μm以下,粒径分布较均匀。
Supercritical antisolvent (SAS) process was a recently developed technology to produce micro- and nano-particles. This paper presents a continuous apparatus to conduct SAS process experiments. Ethylcellulose microparticles by SAS obtained when ethanol was used as organic solvent and supercritical CO2 was used as antisolvent. With the apparatus, the effects of pressure, temperature, CO2 flow rates and solution concentration on the shape, size and distribution of the particles were studied for the ethylcellulose-ethanol-CO2 system. The experimental results show that ethylcellulose microparticles with least diameters to 1 μm and distribution of the particles narrow.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2005年第6期921-922,926,共3页
Journal of Functional Materials
基金
国家自然科学基金资助项目(20176003)
关键词
超临界反溶剂过程
乙基纤维素
超细微粒
Carbon dioxide
Ethanol
Particle size analysis
Solvents
Supercritical fluids
