摘要
[目的]探讨古拉定对活动性肝硬化的治疗意义。[方法]选择活动性肝硬化患者189例,随机分为治疗组106例,对照组83例。治疗组在综合治疗(甘利欣、肝细胞生长素、人血清蛋白、新鲜血浆等)基础上,用古拉定1.2g、静脉滴注,2次/d。疗程为6～8周。对照组,除不用古拉定外,其他治疗相同。[结果]治疗组主要症状和体征的改善明显优于对照组(P<0.05,<0.01),丙氨酸氨基转移酶、总胆红素、血清清蛋白、凝血酶原活动度的改善明显优于对照组(P<0.05),并发症明显低于对照组(P<0.05)。[结论]古拉定治疗活动性肝硬化,有较好的辅助治疗效果。
Objective] To explore the clincal significance of glutathione in adjuvant treatment of active hepatic cirrhosis. [Methods] One hundred and eighty-nine patients (male 163 and female 26, mean age 58.3±16.7 years) were divided into two groups: treatment group (n=106) and control group (n=83). Patients in the treatment group were given 1.2 g glutathione in 100 ml (0.9%) saline intravenous drip, twice a day, for 6-8 weeks, combined with diammonii glycyrrhizinate, hepatic growth factor, albumen and fresh plasma etc, while patients in the control group given synthetic treatment without glutathione only.[Results] Improvement of symptoms and signs in the treatment group was better than that in the control group (P<0.05, <0.01). Changes of serum albumen, bilirubin, alanine aminotransferase, prothrombin activity in the treatment group were superior to those in the control group (P<0.05). The complication of treatment group was lower than that of control group(P<0.05). [Conclusion]Adjuvant treatment of active hepatic cirrhosis showed better therapeutic efficacy.
出处
《中国中西医结合消化杂志》
CAS
2005年第3期167-169,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
肝硬化
活动性
古拉定
hepatic cirrhosis, active
glutathione
