摘要
观察了贵州苦茶叶对兔高脂动物模型血脂质代谢、动脉粥样硬化等的影响。结果苦茶叶组用药后１、２、３个月血总脂、总胆固醇较对照组降低（Ｐ＜０．０５）；用药后１、２个月测定血过氧化脂质较对照组低（Ｐ＜０．０５）；３个月末剖杀动物见主动脉动脉粥样硬化面积小于对照组（Ｐ＜０．０１）；红细胞压积３个月末亦较对照组低（Ｐ＜０．０５），与安妥明组结果相近。表明贵州苦茶叶具有降低血脂、降低血过氧化脂质、抗动脉粥样硬化、降低红细胞压积，从而改善了血液流变性的作用。动物急性和亚急性毒性实验表明其安全、无毒。
The results of treatment with the Ligustrum japonicum Thunb.Var.Pubescens Koidz (LJ) in rabbits'model of hyperlipemia and atherosclerosis was observed.The results showed:(1)By the end of first to third month,the levels of serum TL and TC in groups B,C were lower than that of group A and there was significant difference between them(P<0.05),the level of serum TG in groups B,C was lower than that of group A too,but there was no significant difference between them(P>0.05).(2)By the end of first and second month, the level of serum LPO in groups B,C was lower than that of group A and there were significant difference between them(P<0.05,0.01), while there was no significant difference between group B and group C(P>0.05).(3)The rabbits were sacrificed by the end of third month, arteriosclerotic area of aorta in groups B,C were less than that of group A,and that of group B was even less than group C, there was significant difference between group A and B (P<0.01).(4)By the end of third month,the level of HCT in groups B,C was lower than that of group A and there was significant difference between them (P<0.05) ,but there was no significant difference between group B and group C(P>0.05).These results showed that LJ could lower the levels of serum TL,TC,LPO,HCT and anti-arteriosclerosis as well,it could prevent cerebro-and cardio-vascular disease as the clofibrate.The results of acute and subacute toxicological tests proved that the LJ was a non-toxic medicinal plant.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第11期670-672,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
苦茶叶
过氧化脂质
动脉粥样硬化
红细胞压积
Ligustrum japonicum,lipid,lipid peroxides,atherosclerosis,hematocrit,toxicological test
