摘要
目的探讨细胞周期素D1(cyclinD1)在涎腺腺样囊性癌中的表达及其与涎腺腺样囊性癌的相关性。方法采用免疫组织化学SP法检测cyclinD1蛋白在12例正常涎腺组织(NSG),15例多行性腺瘤(PA)及41例涎腺腺样囊性癌(ACC)中的表达。结果cyclinD1在NSG、PA及ACC中的表达率分别为0、53.3%、68.3%,NSG与PA、ACC组差异均有统计学意义(P<0.05),PA与ACC组表达水平差异有统计学意义(P<0.05)。cyclinD1在晚期病例中的阳性表达率和表达水平均高于早期病例,其差异有统计学意义(P<0.05)。结论cyclinD1的高表达在涎腺腺样囊性癌的发生发展中起重要作用,检测其表达水平可用以辅助腺样囊性癌诊断及估计预后。
Objective To observe the expression of cyclin D1 in human adnoid cystic carcinoma and its correlation with clinical characters.Methods The expression of cycline D1 was evaluated with immunohistochemical method in forty-one cases of human adnoid cystic carcinoma, 15 cases of PA and 12 cases of normal salivary gland tissue.Results The expression of cyclin D1 in normal tissue was negative, significantly different from PA and ACC (P<0.05). The expression level of PA was significantly lower than ACC (P<0.05). High expression of cyclin D1 was correlated with clinical stage and histological classification (P<0.05), but not with sex, age, tumor site, recurrence, metastasis.Conclusion High expression of cyclin D1 promotes the formation and development of ACC.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2005年第3期191-193,共3页
West China Journal of Stomatology
基金
高等学校博士学科点专项科研基金资助项目(20040610079)
