摘要
目的观察并比较阿加曲班注射液不同给药方法对慢性动脉闭塞症患者的疗效及安全性。方法将26例患者随机分为A、B两组。A组(11例)给予阿加曲班注射液10mg/次(10mg/支),以250ml葡萄糖注射液或生理盐水注射液稀释,2次/d,总疗程为4周。B组(15例)给予阿加曲班注射液20mg/次,以250ml葡萄糖注射液或生理盐水注射液稀释,2次/d;给药5d后改为1次/d,再连用5d,总疗程为10d。观察两组用药后患肢冷感、麻木感、静息痛、间歇性跛行、溃疡等的改善情况及不良反应的发生情况。结果A组治疗总有效率为72.7%(8/11例),B组为80.0%(12/15例)。两组均无出血等严重不良反应发生。结论两种给药方法对中、重度慢性动脉闭塞症均有效;B组前5天的冲击治疗对重症溃疡患者的疗效更佳、见效更快且更经济;两种给药方法的安全性相同。
Objective To compare the effectiveness and safety of Argatroban in different dosages and courses of treatment in arteriosclerosis obliterans patients. Methods According to preset criteria, 26 patients with arteriosclerosis obliterans were enrolled in this study. They were randomly divided into group A (11 patients) and group B (15 patients), receiving the treatment of Argatroban for 4 weeks in group A and 10 days in group B. Then the two groups were assessed by various symptoms and signs, including coldness, numbness, rest pain, intermittent claudication and ulceration for comparison. Results The clinical effective rate in group A was 72.7%, and in group B were 80.0%. Conclusions The two ways of treatment showed similar effectiveness in arteriosclerosis obliterans. The latter way (10 days treatment) remarkably excelled on refractory ulceration and being more economic.
出处
《上海医学》
CAS
CSCD
北大核心
2005年第5期390-392,共3页
Shanghai Medical Journal
