摘要
目的:探讨结肠肿瘤中KAI1的表达及其临床意义。方法:采用免疫组织化学方法检测109例结肠癌原发病灶、13例肝脏转移灶、46例良性结肠肿瘤和28例正常结肠黏膜中KAI1的表达,并与临床病理资料比较分析。结果:28例正常结肠黏膜均表达KAI1。字2检验表明,随着结肠肿瘤病变的发展,在结肠原发病灶、肝脏转移灶和结肠良性病变中KAI1的表达存在明显差异(P<0.001)。并且在早期结肠癌(Ⅰ/Ⅱ期)与晚期结肠癌(III/Ⅳ期)中,KAI1的表达也有明显差异(P<0.01)。结论:在Ⅲ、Ⅳ期以及发生肝脏转移的患者中,KAI1的表达明显下降。结肠癌中KAI1表达与其病变发展呈负相关,KAI1表达的降低可能是结肠癌病人预后不良的标志之一。
Objective: To investigate the expressive significances of the KAI1 metastasis suppressor gene in colon tumors. Methods: The expressions of KAI1 gene were examined by immunohischemistry in 109 primary tumors, 13 metastatic tumors, 46 benign tumors and 28 normal colon mucosa. In addition, these results were compared with the clinicopathological data. Results: All 28 normal colon mucosae had KAI1 positive expression. Using ?字2 analysis, the decrease of KAI1 protein expression was strongly associated with the progression of colon tumors from benign lesions to primary and liver metastatic cancer(P < 0.001). To be further,when the 109 patients with primary cancer were analyzed,the KAI1 expression showed significant differences between early stage(stageⅠ/Ⅱ) and late stage(stageⅢ/Ⅳ) tumors(P < 0.01). Conclusion: It obviously decreased when the lesion lies in Ⅲ,Ⅳ stages or liver metastasis. The expressions of KAI1 were inversely correlated with the progression of colon cancer and the decreasing KAI1 expression may be an indicator for a poor prognosis in patients with colon cancer.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2005年第7期492-494,F004,共4页
Journal of Nanjing Medical University(Natural Sciences)
