摘要
小脑浦肯野细胞(Purkinjecells)及脑干神经元脱失和脊髓传导通路退变是大多数共济失调的主要形态学改变。近年来,国外研究主要集中在其发病机制上。遗传谱系分析和基因研究已经鉴定出不同的基因型。本文就脊髓小脑共济失调的分类、临床特征和发病机制的研究作一综述。
Loss of cerebellar Purkinje cells,neurons of brain stem and degeneration of spinal ciruits are major morphologic changes in most patients with ataxia.Studies on spinocerebellar ataxia have focused on pathogenesis in recent years. Different genotypes have been identified by genolineage analysis and gene study. This study reviews the literatare on the classification,clinical features and pathogenesis of spinocerebellar ataxia.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2005年第6期692-695,共4页
Academic Journal of Second Military Medical University
