摘要
孕康口服液对针刺和缩宫素所致的大鼠和小鼠实验性流产模型有明显的保胎作用，其疗效与黄体酮无差异；对大鼠、小鼠的离体子宫和家兔在体子宫平滑肌均有明显的松弛作用，并能拮抗缩宫素和乙酰胆碱收缩动物离体和在体子宫平滑肌的作用。毒性试验结果：小鼠和大鼠灌胃的最大耐受量分别大于２４０ｇ／ｋｇ和９６ｇ／ｋｇ，小鼠腹腔注射的ＬＤ５０＝６１．５６±５．２９ｇ／ｋｇ（Ｐ＝０．９５）；大鼠长期毒性试验未见明显毒性；致突变试验阴性；孕鼠服用后未见仔鼠畸形，以及对子代的生长发育和学习记忆无明显影响。
Yunkang oral liquid(YK) had an obviously anti-abortional effect on the abortional testing model of both rats and mice,which was induced by acupuncture and oxytocin(P<0.05,P<0.01);there is no statistic difference between the effect of progesterone and the effect of YK. The results showed that YK could relax obviously the uteri of both rats and mice in vitro and the uteri of rabbits in vivo.It also could antagonize the effects of oxytocin and acetylcholine on animals uteri in vivo and in vitro(P<0.01,P<0.05).The acute toxicologic test showed the maximal tolerance dose of ig.in mice and rats were higher than 240 g/kg and 96 g/kg respectively.The LD50 in mice(ip.) was 61.56±5.29g/kg(p=0.95).Subacute toxicologic test for 8 weeks of continuous drug feeding among rats did not show obvious toxicity.Mutagenicity test also showed negative results.Feeding to pregnant rats with YK did not result in teratogenicity to the offsprings.The growth and development,memory of filial generations were not affected,either.So Yunkang oral liquid,a Chinese compound recipe,has a safe and reliable effect of anti-abortion.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第7期418-420,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
孕康口服液
针刺
动物模型
流产
Yunkang oral liquid,anti-abortional effect,animal abortional model,acupuncture
