摘要
以羟丙基甲基纤维素（ＨＰＭＣ）为基质制备米非司酮（１）分散体的粘贴膜剂。其体外溶出及经粘膜渗透均比常规的１片剂快。月桂氮 酮能加速膜剂的渗透速率，但对片剂并无作用。差示热分析研究表明米非司酮／ＨＰＭＣ固态分散体中１以分子状态存在。
The mifepristone vaginal mucosal adhesive films from mifepristone (1)/HPMC dispersions were prepared. The dissolution rate and permeation rate of 1 in films were faster than those of 1 in the conventional tablets. The enhancer laurocapram improved the permeation rate of 1 in the films,but not in the tablets.The DSC and SEM studies showed that 1 existed in molecular forms in the matrix of HPMC.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1994年第5期204-207,共4页
Chinese Journal of Pharmaceuticals
基金
上海市计划生育委员会资助
关键词
米非司酮
粘贴膜剂
体外释药
mifepristone, vaginal mucosal adhesive film, release in vitro, permeation test, solid dispersion.
