摘要
目的:探讨抗氧化剂(VitE,VitC,Se)对大鼠骨生物力学特性、横断面和骨矿含量变化的影响。方法:实验以36只SD大鼠为实验对象,分为对照组(n=18)、抗氧化试验组(n=18),两组除生活环境、饲料相同外,抗氧化剂组每天灌喂VitE(50mg/kg),、VitC(100mg/kg)和Se剂(15μg/kg),共喂服6周。处死后取双侧股骨和第五腰椎制成试件,在日产万能实验机和力学参数测试系统中做三点弯曲和椎体压缩的生物力学特性测试(弹性模量、最大载荷、屈服应力、最大应力能量吸收等)及对骨的横断面积和骨矿含量进行测定。结果:试验显示,在本实验条件下,抗氧化剂组与对照组比较股骨三点弯曲测试,除其弹性模量、屈服应变、破坏应力无明显变化外(P>0.05),其最大载荷、屈服应力和能量吸收都有不同程度的降低(P<0.05),而横断面积(P>0.05)和骨矿含量(P<0.05)则有所提高,腰椎压缩实验结果显示其各项指标虽有变化,但尚无显著性差异(P>0.05)。结论:这似乎表明,抗氧化剂虽对骨的生长(骨横断面、骨矿含量)有一定影响,一些生物力学指标变化可能是生长过程中的塑形。总的来看,对其生物力学特性的影响不如应力发生变化的影响明显。有关抗氧化剂如骨生长发育和生物力学参数变化的影响尚需更加深入广泛的研究。
Objective To investigate the effects of Antioxidants on the biomechanics charact eristics and growth of femur and vertebral bone in rats. Method 36 SD rats were randomly divided into control group (n=18) and Antioxidants group (n=18) with Vi tE(50mg/kg),VitC(100mg/kg) and Se(15μg/kg) per day and last 6weeks. The fresh b ones of femur and vertebrae were take as specimens to produce test sample, the t hree-point bending and compression test were used to test the samples on the com puterized multifunction test machine for the biomechanics parameters and the sta ndard statistic test were used to analyze. Result The result and analysis showed that place the different changes, the elastic model, the yield strain and maxim um stress changed not remarkably(P>0.05), but the maximum load, the yield stress and the energy decreased significantly(P<0.05), the amount of bone mineral para meters increased(P<0.05). Vertebrae compressive test showed that the parameters and the amount of bone mineral parameters increased but not significantly (P>0.0 5). Conclusion The result suggested that the biomechanics characteristics of bor n and growth could be affected by Antioxidants but it needs to be further studie d.
出处
《成都体育学院学报》
CSSCI
北大核心
2005年第3期83-86,共4页
Journal of Chengdu Sport University
基金
国家自然科学基金课题(1007205)的部分研究成果。
