摘要
本文研究了Ｅ－４０３１和利多卡因伍用对大鼠血流动力学的影响。结果表明，大鼠血压从给药前的１２．８７±０．９１ｋＰａ降至１１．６０±０．８１ｋＰａ（Ｐ＜０．０１）；左室压从给药前的１１．５９±０．８０ｋＰａ降至９．４９±０．７７ｋＰａ（Ｐ＜０．０１）；ｄｐ／ｄｔ＿（ｍａｘ）从给药前的２５３１±１７６．０ｍＶ／ｓ降至２０１４±１７０ｍＶ／ｓ；－ｄｐ／ｄｔ＿（ｍａｘ）从给药前２３４６±１７５ｍＶ／ｓ降至１９７８±１５９．０ｍＶ／ｓ。而同剂量的Ｅ－４０３１和利多卡因则无上述抑制作用。提示两药伍用时心率失常患者应注意心功能状态，用量不当可能使患者血压下降，心肌收缩无力，造成心肌缺血或诱发心衰。
he study of the effects of E-4031 and lidocaine on
the hemodynamics in rats showedthat E-4031 and lidocaine together in
administration could decrease the blood pressure(Bp)sig-nificantly in
rats:blood pressure of the control from 12.83±0.90 to 11.57±
0.81kPa(P< 0.01 and low left ventricular pressure (LVP)from 11.56±0.
76 to 9.47±0.77kPa(P<0.01),andcould inhibit +dp/dt_(max) from 2531.3
±175. 8 to 2014.0±169.7m V/s(P<0.01) and -dp/dt_(max)from 2346.0±
175.3 to 1978.0±159.4 mV/s(P<0.05).Bp,LVP and ±dp/dt_(max) were
decreasedafter combined use of E-4031 and lidocaine.In same
dose,however, both E-4031 and lidocaine didnot affect above
parameters.These indicated that the state of cardiac function should
be consid-ered carefully when E-4031 and lidocaine were administrated
jointly to the patient with arrhyth-mia and heart failure may be
induced if the dose of both drugs is large.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1994年第5期276-278,共3页
Chinese Pharmaceutical Journal
关键词
E-4031
利多卡因
血液动力学
E-4031,lidocaine,heart rate,blood pressure,±dp/dt_(max),LVP
