摘要
米帕林对β－肾上腺素能受体的作用邢成，季少平，王鲁明，吕宝璋（北京军事医学科学院基础医学研究所，北京１００８５０）米帕林（ｍｅｐａｃｒｉｎｅ，Ｍｅｐ）是磷脂酶Ａ，及磷脂酶Ｃ的抑制剂，也是一种膜稳定剂［１］．我们曾证实它在磷脂代谢和对β－肾上腺素能受体...
In order to identify the effects ofmepacrine on β-adrenergic receptor(β-AR). radio-ligand binding assays were taken to compare the ef-fects of mepacrine inhibiting to[3H]dihydroalprenolol([3H]DHA) binding to β-AR with that of β-ARagonist and antagonist, and the effects of mepacrineon β-AR effectors were investigated simultaneously us-ing biochemical and pharmocological methods. The re-sults demonstrated that mepacrine activate β-AR andprod uce its biologic effects,such as,increase ofintracellular cAMP level.decrease of content of liverglycogen,enhance of lipolysis of adipocyte and relaxa-tion of uterine smooth muscle.These data indjcatedthat mepacrine mav be one of the β-AR agonists.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1994年第4期307-308,共2页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金
关键词
米帕林
肾上腺素能
受体
药理学
receptor,adrenergic,beta
mepacrine, adenosine cyclic 3,5-monophosphate
fatty acids, nonesterified
