摘要
阿斯匹林与奥昔麻黄碱均抑制ＡＤＰ诱导的大鼠体内血小板聚集和实验性脑血栓形成．滞后电刺激大鼠颈动脉血栓形成时间．减少肾上腺素和胶原复合诱导剂静注所致小鼠肺血栓造成的死亡．剂量与效应相关．两者合用作用增强．
The effects of Aspirin(ASA),Oxyfedrine(OXY)and ASA+OXY on plateletaggregation and generation of thrombosis werestudied.ASA and OXY respectively inhibitedplatelet aggregation in vivo induced by ADP andexperimenta cerebral thrombosis,and postPonedthe time of thrombosis induced by eletrical stimulation of the carotid artery in rate,also reducedthe death rate resulted from pulmonary thrombosis induced by inducer composed of collagen andepinephrine(iv)in mice.The effects Of combination of ASA and OXY markedly increased.Meanwhile,all of those effects showed good dose-dependent manner.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1994年第3期211-213,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金
关键词
阿斯匹林
奥昔麻黄碱
血小板聚集
Aspirin
Oxyfedrine
platelet aggregation
cerebral thrombosis
carotid artery thrombosis
pulmanary thrombosis
