摘要
静脉输入3’-当归酰氧基-4’-乙酰氧基-3’,4’-双氢邪蒿内酯(0.15mg·kg^(-1)·min^(-1))30min对15min闭塞犬左前降枝伴3h再灌注后心肌收缩功能的影响被研究。用超声微测距法测定心肌节段收缩(SS)长度表明:该药迅速改善心肌收缩功能不良,再灌后5min即使SS％恢复到用药前的41±51％(P<0.05,n=8),对血流动力学无明显影响。
The effect of a 30-min infusion of 3'-angeloyloxy-4'-acetoxy-3', 4'-dihydro-seselin (Pd-Ia), a coumarin isolated from Peucedanum praeruptorum Dunn 0.15 mg ·kg1·min-1 on regional myocardial dysfunction was examined in 16 anesthetized open-rhest dogs subjected to a 15-min occlusion of the left anterior descending coronary artery followed by a 3-h reperfusion. Segment lengths of left ventricular wall were measured with an ultrasonic micrometer. The control caused a decrease in the % of segment shortening (SS %) throughout the reperfusion period (n = 8), while Pd-Ia ameliorated segment function immediately after reperfusion and re-stored the SS % to 41 ±51 % of the baseline value (n = 8, P<0. 05 vs control) 5 min after reperfusion without any significant changes in cardiohemodynamics. The improvement of myocardial function induced by Pd-Ia was maintained at least 3 h after reperfusion. These findings revealed that Pd-Ia had a car-dioprotective action in stunned myocardium.
出处
《中国药理学报》
CSCD
1994年第5期388-391,共4页
Acta Pharmacologica Sinica
关键词
血流动力学
香豆素类
超声波描记
coumarins
myocardial reper- fusion injury
hemodynamics
ultrasono- graphy
