摘要
临床实践及动物实验均表明ＶｉｔＫ３有镇痛作用。本实验发现ＶｉｔＫ３（６４ｍｇ·ｋｇ－１．ｉｐ）急性用药可使Ｗｉｓｔａｒ大白鼠脑内亮氨酸脑啡肽含量在尾壳核升高４３％（Ｐ＜０．０１）．在下丘脑升高４５％（Ｐ＜０．０５）。ＶｉｔＫ３（１．９６×１０－５～６．２９×１０－４ｍｏｌ．Ｌ－１）剂量依赖性地部分抑制低频电刺激引起的豚鼠回肠收缩，其效价约为吗啡的１／５０００。上述结果提示ＶｉｔＫ３的中枢镇痛作用可能与某些脑区内脑啡肽增多有关。
E fects of itamin K3(Vit K3) onthe content of len-enkephalin(LEK)in rat brainand the contraction of gu nea-pig ileum(GPI)were studied, Vi K3(64 mg. kg-1)enhanced thecontent of LEK by 43% (P<0. 01) in caudateputamen nucleus and by 40% (P<0.05)in hypothalamus of Wistar rat, and the content ofLEK were not changed in hippocampus and thalamus. Vit K3(1.96×105￣6.29×10-4mol.L-1) partially inhibited the contraction of GPIevoked by low frequecy electrical stimulation,and its potency was about one- 5000th ofmorphine's. Vit K3 did not significantly changethe effect of morphine on the contraction ofGPI. The results suggested that the analgesic action of Vit K3 may involve in the increase of LEK in some brain areas, and may not affect in opium μ receptor directly.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1994年第1期18-20,共3页
Chinese Pharmacological Bulletin
关键词
维生素K3
亮氨酸脑啡肽
豚鼠
回肠
vitamin K_3(Vit K)
leuenkephalin
guinea-pig ileum (GPI)
morphine(Mer)
