摘要
目的观察纤溶酶(Fibrinogenase)治疗不稳定型心绞痛(UA)的临床疗效和安全性。方法对46例不稳定型心绞痛患者,在常规抗心绞痛治疗的基础上,加用纤溶酶注射液200U加入0.9%生理盐水250ml中,缓慢静滴,1次/d,连用10d,用药期间停用其他溶栓、抗凝、抗纤溶及血小板抑制剂,用药后评价临床疗效及有关实验室指标。结果纤溶酶对心绞痛临床症状总有效率84.8%,心电图(ECG)改善总有效率67.4%,纤维蛋白原(FIBEN)降低(P<0.05)。结论纤溶酶对不稳定型心绞痛患者通过溶栓降纤调节纤溶系统使纤维蛋白原降低,从而明显改善心肌缺血及缓解临床症状。
Objective To observe the effects and safety of fibrinogenase on 46 patients with unstable angina pectoris.Methods 46 patients with unstable angia pectoris were treated 10 days with fibrinogenase(200u add in 250ml physiologic salt water)dripped slowly intravenously, No thrombolytic agents,anticoagulants,an-tiplaminogens or platelet inhibitors were used during the course.The clinical effects and laboratory items were studied after the trial.Results The clinical symptoms were improved in84.8% of the patients with unstable angina,so did ECG results in67.4% of the patients. FIBEN decreased significantly(P<0.05).Conclusions fibrinogenase can de-crease FIBEN,improve clinical symptoms and ECG results of the patients with unstable angina.
出处
《中国煤炭工业医学杂志》
2005年第5期460-461,共2页
Chinese Journal of Coal Industry Medicine
