摘要
目的:探讨脑梗塞(CI)患者血清β淀粉样蛋白(Aβ)水平及其在脑梗塞发生、发展中的关系。方法:采用放射免疫分析法测定30例急性脑梗塞患者(CI组)3～5d、10～14d以及30例正常人(对照组)血清Aβ水平,并测定CI组脑梗塞的体积及患者肢体残损程度。结果:CI组患者发病3～5d血清Aβ水平显著高于发病后10～14d眼(1.2460±0.2517)ng/mlvs(1.1103±0.1825)ng/ml,P<0.05演;10～14d血清Aβ水平明显高于正常对照组眼(1.1103±0.1825)ng/mlvs(0.9885±0.2253)ng/ml,P<0.05演。血清Aβ水平与患者脑梗塞灶的体积及神经功能缺损程度呈正相关(r=0.406,P<0.01)。结论:Aβ参与CI的发生与发展。干扰Aβ的产生,下调其表达,可减轻缺血性脑梗塞及所致的躯体神经功能缺损程度。
O bjective:To study the levels ofserum am yloid β-protein(A β)in cerebralinfarction(CI) and the effectofA β on the occurrence and developm entofCI.M ethods:The levels ofserum A β were de-tected by radioim m unoassay in 30patients with CI within 3～5days and 10～14days after attack and in 30 norm alcontrols)the volum e ofinfarcts with CI and the degree ofdeficiency ofthe extrem ities were detected as well.R esults:The levels ofserum A β of 3～5days after attack were significanthigher than those of10～ 14days [ (1.2460±0.2517 ) ng/m lvs ( 1.1103±0.1825 ) ng/m l, P <0.05 ] .The levels ofserum A β of10～14days were higher than those ofnorm alcontrols [ (1.1103±0.1825 ) ng/m lvs ( 0.9885±0.2253 ) ng/m l,P <0.05 ] .The levels ofserum A β ofpatients with CI were positively correlated with the volum e ofinfarcts as wellas the degree ofdeficiency ofthe nervous system ( r =0.406, P <0.01).C onclusion:A β is involved in the occurrence and developm entofCI.W e The degree ofdeficiency ofsom atic and nervous function caused by ischem ic CI can be alleviated by interfered with its production and expression.
出处
《山东大学学报（医学版）》
CAS
北大核心
2005年第4期353-355,共3页
Journal of Shandong University:Health Sciences
关键词
脑梗塞
Β淀粉样蛋白
血清
Cerebralinfarction)Am yloid β-protein)Serum
