摘要
T淋巴瘤侵袭转移诱导因子1(Tlymphomainvasionandmetastasisinducingfactor1,Tiam1),是Rho样GTPase的GDP分离刺激因子,具有调节细胞骨架结构重组,促进细胞运动的功能。研究表明,Tiam1过表达可以诱导肿瘤细胞侵袭、转移,其分子生物学基础主要基于:Tiam1与肿瘤“细胞骨架-粘附分子-细胞外基质”跨膜系统的相互作用,Tiam1对肿瘤细胞增殖和凋亡的影响,以及其它肿瘤侵袭转移相关因子对Tiam1活性的调控几方面。同时,现有实验结果提示,Tiam1活性调节的多样性和生物效应的特异性,以及Tiam1与其他肿瘤侵袭转移相关因子间的关系及信号转导机制,尚有待深入研究。
As a guanine nucleotide dissociation stimulator (GDS) of Rho-like GTPases, T lymphoma invasion and metastasis inducing factor 1(Tiam 1)possesses such biological functions as regulating reconstruction of cytoskeletal structure and migratory potential of cells. Studies had shown that over-expression of Tiam 1 was able to induce invasion and metastasis of tumor cells, the molecular biological basis of which includes the interactions between Tiam 1 and trans-membrane system of cytoskeleton, adhesion molecules and extra-cellular matrix, the effect on proliferation and apoptosis of tumor cells exposed by Tiam 1, as well as the activities of Tiam 1 regulated by other invasion and meatstasis associated factors. Simultaneously, these experimental results suggested that much more work would be needed in Tiam 1 on the diversity of its activity regulation ,the specificity of its biological effect, the realationship among Tiam 1 with other invasion and metastasis associated factors, as well as their mechanisms of signal transduction.
出处
《中国癌症杂志》
CAS
CSCD
2005年第2期189-192,194,共5页
China Oncology
