摘要
用双抗体夹心ＥＬＩＳＡ检测６６例ＳＩＥ病人血清叽ｓＩＬ－２Ｒ水平，ＳＬＥ病人显著高于正常人，疾病活动期高于非活动期。血清ｓＩＬ－２Ｒ水平与ＡＮＡ、抗ｄｓ－ＤＮＡ抗体、抗Ｓｍ、ＳＳ－Ａ、ＳＳ－Ｂ抗体无关，而与ＳＬＥ患者的发热、贫血、白细胞减少、关节受累及肾脏损害相关，且与ＳＬＥ疾病活动性和ＥＳＲ成正相关，与补体Ｃ＿３、Ｃ＿４和ＣＨ＿（５０）成负相关。提示血清ｓＩＬ－２Ｒ水平是监测ＳＬＥ疾病活动性的一个良好指标。
erum sIL-2R
levels,as measured by a double antibody“sandwich”enzyme linked
im-mumosorbent assay technique,were significantly increased in 66
patients with SLE comparedwith 24 healthy controls and were higher in
active than inactive SLE. No statistical signtificantdifferences were
observed in the prevalaence of ANA antids DNA、antiSm、RNP、SSA、
SSB、anti-bodies between high and low slL-2R levels.It has been
fotind that the incidence of fever、anaemia、leticopenia、joint and
renal involvement was greater in patients with high slL-2R lev-els. A
significant positive correlation was present between serum slL-2R
levels and SLE diseaseactivity and ESR either.Whereas the slL-2R
levels in SLE patients were inversely correlatedwith levels of C_3、
C_4 and CH_(50).Our fi11dings indicate that serum sIL-2R levels may
serve as a sen-tqitive and quantitive marker to monitor the disease
activity
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第3期177-179,共3页
Chinese Journal of Immunology
关键词
红斑狼疮
白细胞介素2
受体
Systemic lupus erythematosus(SLE)Soluble
interleukin-2 receptop(sIL-2R)
