摘要
对ＳＤ鼠采用主动免疫法建立血清抗精子抗体（ＡＳＡｂ）阳性的动物模型，并用具有滋肾补肾、活血化瘀作用的助孕Ⅰ号方、Ⅱ号方，于建模时同期通过灌胃给药进行实验，观察其对ＳＤ鼠血清ＡｓＡｂ的影响。结果表明，助孕Ⅰ号、Ⅱ号方组ＳＤ鼠的血清ＡＳＡｂ阴性率明显高于对照组（Ｐ＜０．０５及Ｐ＜０．０１）。说明二方均具有抑制ＡＳＡｂ产生的作用。为中医中药治疗抗精子免疫性不育提供了动物实验依据。
ntisperm
antibody (ASAb) positive model rats were made by injection of human
semen.The rats were treated in the same period of model establishment
with Zhu Yun Ⅰ and Ⅱ by in-fusing into stomach. Zhu Yun Ⅰ and Ⅱ
were compared with herbal medicines for tonifying thekidney and
promoting blood stasis. In the result of this experiment,it was
showed that the nega-tive rate of rat serum in both groups of Zhu Yun
Ⅰ and Ⅱ was significant higher than controlgroup (P<0.05 and
P<0.01).The data indicates that both recipes have inhibitory effect
onASAb producing;It provides evidence in animal experiment for
Chinese herbal therapy on im-munologic infertility with ASAb.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1994年第1期44-46,共3页
Chinese Journal of Immunology
基金
国家中医药管理局科研基金
关键词
抗体
抗精子
中医药疗法
不育症
antisperm antibody immunologc infertility with ASAb TCM
therapy
