摘要
应用反相HPLC法,比较了8名健康志愿者单剂量口服300mg利巴韦林胶囊与口服液(温洲第三制药厂和上海天丰制药厂)的相对生物利用度,并计算了药代动力学参数.研究结果显示,利巴韦林口服后的体内过程为一级吸收和二相消除,与国外文献报道一致.胶囊剂与口服液的达峰时(T_(max))分别为1.05±0.18h和1.06±0.36h,峰浓度分别为0.333±0.054 mg/1和 0.358±0.095mg/1,消除半衰期T_(1/2β)分别为 22.08±3.61h和24.84±8. 79h,二种剂型的T_(max),C_(max),T_lag,K_a,AUC均无显著性差异(P>0.05),胶囊剂对口服液的相对生物利用度为98.63%.
Eight healthy aldult volunteers received single 300 mg oral doses of ribavirin capsules orsolution made by Wen-zhou Third Pharmacutical Factory and by Shaihai Tian feng Pharmacuetical Factory respectively. The relative bioavailablity was estimated and the pharmacokinetic parameters were calculated. The result showed that ribavirin in human was of first -order absorbtion and biphasic elimination. All parameters were similar with those reported in the literature. The peak serum level of the capsules and the solution reached 1. 05±0. 18 h and 1. 06±0. 36 h, respectively. The elemination half-time (T1/2β) were 22.08 ± 3.61 h and 24.84 ± 8.79 h, respectively. The Tmax, Cmax, Tlag, Ka, AUC had no significant difference between the two dosage forms (P>0.05). The relative bioavailability of ribavirin capsules to solution is 98.63%.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1994年第3期177-180,共4页
The Chinese Journal of Clinical Pharmacology
