摘要
采用肉汤稀释法和纸片法测定９４株临床分离病原菌对β－内酰胺抗生素的敏感性和检测病原菌的β－内酰胺酶５０株（５３．２％）对氨苄青霉素耐药，其中４７株（９６．０％）β－内酰胺酶阳性；对舒他西林耐药６株（６．４％），５株检出β－内酰胺酶对头孢噻肟耐药３株（３．２％），２株含β－内酰胺酶表明β－内酰胺酶的产生是金葡球菌、大肠杆菌、肺炎杆菌及其它杆菌耐上述三种β－内酰胺抗生素的主要原因。因此，β－内酰胺酶的测定，对临床合理应用抗生素具有重要意义，β－内酰胶酶抑制剂与β－内酰胺抗生素联用是治疗耐药菌的有效途径之一。
clinical bacterial strains were studied for their sensi-tiviy to Ampicillin, Unasyn (ampicillin/sulbactam) and cefotaxime,and their β-lactamases,Results show that 50 strains(53.2%)were resiStant to Ampicillin,6 strains( 6.4%)were resistant to Unasyn(containig β-lacta-mase inhibitor),Onlr3(3.2%)resisant to cefotaxilne(stable to β-lacta-mases).-Lactamase positive in 47 of 50 ABPC-resisitant strains, 5 of 6 Unasyn-resistant strains, 2 of 3 CTX-resistant stratns respectively, The mechanism of bacterial resistance against common used β-lactam antibi-otics was also discussed.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1994年第6期437-439,共3页
Chinese Journal of Antibiotics
