摘要
二甲胺四环素（Ｍｉｎｏｃｙｃｌｉｎｅ，ＭＩＮＯ）为四环素族抗生素中抗菌活性最强的一种，抗菌谱广，口服吸收良好。本研究用ＭＩＮＯ治疗１００例轻中度消化道、泌尿道、呼吸道感染及其他感染，其中５０例与强力霉素（Ｄｏｘｙｃｙｃｌｉｎｅ，ＤＯＸＹ）随机对照。剂量均为１００ｍｇ，１天２次，首剂加倍。结果示随机对照组ＭＩＮＯ和ＤＯＸＹ有效率分别为９６．７％和６８％（ｐ＜０．０５），有显著差异。细菌阴转率分别为９０．９％和７６．９％（ｐ＞０．０５）。ＭＩＮＯ治疗开放组感染５０例，有效率为９８％，细菌阴转率为８７．２％。ＭＩＮＯ组总副反应率为２５％，主要表现为头昏和恶心，未见肝肾功能损害。体外抗菌活性显示ＭＩＮＯ对金葡球菌有较强的抗菌活性，ＭＩＣ９０为２ｍｇ／Ｌ，但对革兰氏阴性杆菌抗菌活性较差。
patients with fIlild or mioderate bacterial gastrointest-inal,urinary,respiratory tract and soft tissue infections were randomized to receive either Minpcycline or Doxycyline orally for 7～14 days.The dosage schedule for two antibiotics were both 200mg initially followed by 100mg every 12 hours.In the Minocycline group(50 patients),96.7%of the patients were clinically cured or lnarkedly ilnproved as compared with 68%of the pati-ents in the Doxycycline group(50 patients)(P<0.05),Tlie bacterial era-dication rate was 90.9%in the Minocycline group as eofnpared with Dox-ycycline group.The side effects of Minocycline were miid in degree and consisted of dizzhess and nausea.No toxic hematologic changes occurred,as well renal or liver functions tests. An additional 50 patients were treated by Minocycline in an open trial,98%of the patients were clinically cured or markedly improved,and 87.2%of the pathogens were eradicated Minocycline had good antibacterial activity against Staphylococcus aureus in vitro,but had less activities against Gram-negative bacteria.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1994年第1期35-41,共7页
Chinese Journal of Antibiotics
