摘要
酮替酚或周效磺胺单独使用治疗疟疾，红内期约氏疟原虫的超微结构均能受到一定的损伤，但配伍使用酮替酚和周效磺胺后虫体的结构损伤更为迅速，给药８小时后裂殖体形成受阻，滋养体除细胞结构逐渐消失外还出现伪食泡和逐渐增多增大的单膜或多膜空泡，给药２４小时未查见结构完整的滋养体。
he effect of ketotifen combined withsulfamethoxin on the ultrastructure of the ery-throcytic stages of Plasmodium yoelii was stud-ied in comparison with that of only ketotifenor only sulfamethoxine.The results showedthat the combination killed the parasites morerapidly.In the case of only ketotifen wasused,24 hours after administration,therewere still a few of merozoites and trophozoitesalive.In the case of only sulfamethoxine,there were still some trophozoites alive at thesame time,though the formation of merozoitewas stuck.When using both of ketotifen andsulfamethoxine,8 hours after administration,there was no merozoite formed ,and 24 hoursafter administration there was no intacttrophozoite being observed.The most promi-nent changes of parasites treated with mixtureof drugs were the appearance of many falsefood vesicles and vacuolus with mono or poly-membrane.
出处
《中国寄生虫病防治杂志》
CSCD
1994年第4期262-265,共4页
Chinese Journal of Parasitic Disease Control
