杏仁复合体β受体参与条件性恐惧记忆被引量：2

β-adrenoceptors in amygdala are involved in conditioned fear memeory

导出

摘要杏仁复合体是条件性恐惧记忆形成和储存的关键脑区。杏仁复合体β受体参与条件性恐惧记忆的巩固。β受体激活易化杏仁复合体内突触传递的长时程增强,增强条件性恐惧记忆的巩固;而阻断β受体则抑制杏仁复合体内突触传递的长时程增强,损害条件性恐惧记忆的巩固。

作者刘欣秋李葆明

机构地区复旦大学神经生物学研究所

出处《生理科学进展》 CAS CSCD 北大核心 2005年第2期163-165,共3页 Progress in Physiological Sciences

基金国家杰出青年科学基金(30225023) 国家重点基础研究发展规划项目(G1999054000)资助课题

关键词 Β受体杏仁复合体条件性恐惧记忆

参考文献10

1LeDoux JE, Cicchetti P, Xagoraris A, et al. The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning. J Neurosci, 1990, 10:1062～1069.
2Roozendaal B, McGaugh JL. Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. Neurobiol Learn Mem, 1997, 67:176～179.
3Swanson LW, Petrovich GD. What is the amygdala? Trends Neurosci, 1998, 21:323～331.
4McGaugh JL. Memory consolidation and the amygdala: a systems perspective. Trends Neurosci, 2002, 25:456～461.
5Schafe GE, LeDoux JE. Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J Neurosci, 2000, 20:RC96:1～5.
6McGaugh JL. Memory--a century of consolidation. Science, 2000, 287:248～251.
7Gallagher M, Kapp BS, Musty RE, et al. Memory formation: evidence for a specific neurochemical system in the amygdala. Science, 1977, 198:423～425.
8Duvarci S, Nader K. Characterization of fear memory reconsolidation. J Neurosci, 2004, 24:9269～9275.
9Mayford M, Abel T, Kandel ER. Transgenic approaches to cognition. Curr Opin Neurobiol, 1995, 5:141～148.
10Huang YY, Martin KC, Kandel ER. Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. J Neurosci, 2000, 20:6317～6325.

1李东培,汪华侨,姚志彬.脑nestin-ir神经元的发现-形态、化学、投射和功能[J].神经解剖学杂志,2004,20(6):641-643. 被引量：8
2王细林,曾庆杏,杨波.N-Methyl-D-Aspartate受体拮抗剂对大鼠海马神经干细胞内源性激活的实验研究[J].卒中与神经疾病,2004,11(6):333-337. 被引量：2
3陈晔武.知识创新的三重螺旋运动模型[J].情报科学,2005,23(2):171-174. 被引量：33
4肖久灵,颜光华.组织知识内化的学习机制研究[J].科学学与科学技术管理,2006,27(6):164-168. 被引量：10
5SCHARMER C O. Self-transcending knowledge: sensing and or- ganizing around emerging opportunities [ J]. Journal of Knowl- edge Management, 2001 (5) : 137-150.
6http: //baike. baidu, corn/view/86546, htmJHJsub86546.
7Tang Ya-Ping,Dube GR,et al.Genetic enhancement of learning and memory in mice[J].Nature,1999,401(6748);63-69.
8Shimizu E,Tang YP,et al.NMDA reeeptor-dependent synaptic reinforcement as a crucial processformemory consolidation[J].Seience,2000,290(5494);1170-1174.
9Pham,Kara,MeEwen,Bruce.Stress and hippoeampal plasticity[J].Dissertation Abstracts International,2002,63(5);2234.
10Kojima N,Sakamoto T,et al.Impairment of conditioned freezing to tone,hut not to context,in Fyn-transgenie mice:relationship to NMDA receptor subunit 2B function[J].The European Journal of Neuroscience,2005,21(5);1359-1369.

1史萌,时燕薇,赵虎.条件性恐惧记忆形成中大鼠海马CA1/CA3区Hsp90表达变化[J].热带医学杂志,2015,15(4):450-453. 被引量：2
2孙楠,魏艺铭,李倩,郑希付.条件性恐惧记忆消退返回的性别差异[J].心理学报,2012,44(3):314-321. 被引量：7
3田玉娥,刘江杰,张燕,李敏,张永亮.普萘洛尔对条件性恐惧大鼠恐惧记忆保持与海马CA3区神经元形态的影响[J].第三军医大学学报,2011,33(12):1207-1210. 被引量：2
4秦雯,曲睿,汪萌芽.大鼠创伤后应激障碍模型及腹腔注射干预的影响[J].皖南医学院学报,2012,31(5):349-353. 被引量：1
5罗峻,隋建峰,林建雄,李希成.催产素对低氧大鼠海马脑片CA1区LTP的影响[J].第三军医大学学报,2003,25(3):275-276.
6唐玲,唐荣伟,唐晶,任筠筠.突触可塑性与学习记忆关系的研究进展[J].川北医学院学报,2012,27(1):89-92. 被引量：18
7李丽,王淑珍,王庭槐.海马N甲-基-D-天冬氨酸受体与学习记忆关系的研究进展[J].医学综述,2009,15(10):1452-1455. 被引量：5
8吕和平,任爱红,武晓洛,王晓兰,陈玲,李智涛.海马在学习记忆中的作用研究进展[J].洛阳医专学报,2002,20(4):354-355. 被引量：8
9肖鸿美,张自东.铝对大鼠海马CA＿3区突触传递的长时程增强的阻抑作用[J].同济医科大学学报,1996,25(5):350-353. 被引量：6
10张伟,袁新初.海马LTP的形成机制及进展[J].数理医药学杂志,2002,15(4):366-368. 被引量：8

生理科学进展

2005年第2期

内容加载中请稍等...