摘要
本文报道用华支睾吸虫与二甲基亚硝胺诱发动物肝癌的实验结果。Ａ组每只金地鼠通过胃管人工感染华支睾吸虫囊蚴，３０ｄ后当鼠粪中查见华支睾吸由卵时开始自由饮服０．００２５％二甲基亚硝胺溶液１７周，结果１１只鼠中４只诱发肝癌，１只诱发肝胆管癌和５只肝硬变。Ｂ组每只鼠仅自由饮服０．００２５％二甲基亚硝胺溶液１７周，１５只鼠中３只诱发肝癌，５只肝硬变。Ｃ组每只鼠仅通过胃管人工感染华支睾吸虫囊蚴，不饮服二甲基亚硝胺，１２只鼠中仅６只发生肝硬变。空白对照的１５只鼠均未发现病变。结果显示金地鼠饮服二甲基亚硝胺可引起肝细胞和胆管细胞恶变，而华支睾吸虫在肝内的寄生，可促使肝癌的发生。
This paper reports the results of the experimental animal liver carcinoma inducedby Clonorchis sinensis and dimethyl-nitrosamine(DMN).Golden hamsters in the group A wereinfected artificially with metacercaria of Clonorchis sinensis via gastric tube. Thirty days later,when ova of the flukes appeared in the stool,golden hamsters were allowed to drink 0. 0025%DMN solution freely for 17 weeks. The result showed that,of 11 hamsters,four developed hepat-ic carcinoma,one had introhepatic bile duct carcinoma,and five had cirrhosis. In the group B,eachhamster only drank 0.0025%DMN solution freely for 17 weeks. As the result, of 15 hamsters,3had hepatic carcinoma and 5 had cirrhosis. Hamsters in group C were only treated with metacer-caria of Clonorchis sinensis via the gastric tube. The result was that ,half of 12 hamsters had cir-rhosis. In the control group,no pathological changes could be found in liver in all of the 15 ham-sters. Our experimental results showed that drinking DMN solution may cause malignant changesof hepatocyte and bile duct epithelial cells in hamster and parasitic Clonorchis sinensis may pro-mote the formation of hepatic carcinoma.
出处
《中国寄生虫病防治杂志》
CSCD
1994年第3期201-203,共3页
Chinese Journal of Parasitic Disease Control
基金
国家自然科学基金
关键词
二甲基亚硝胺
肝癌
异形吸虫病
Clonorchis sinensis dimethylnitrosamine hepatic carcinomaThis project was supported by the National Natural Science Foundation of China
