摘要
研究表明,DBTL经口、吸入和经皮染毒均可引起大鼠、小鼠活动和摄食减少、体重下降、口鼻部出现血性分泌物。经口、经皮染毒属中等毒性,其热解产物对呼吸道具有较强的刺激作用。大鼠每天经口染毒1/10LD_(50)的DBTL两周,可引起SGPT活性及SB浓度升高,病理检查见肝细胞变性、坏死及胆管上皮细胞坏死。小鼠孕期第6～15天每日染毒剂量为1/50LD_(50)或更高的DBTL,可引起胚胎死亡率明显增高,但未见明显的致畸作用。枯草杆菌DNA重组修复试验未见DBTL具有致突变性。
In this study, decreased ac ivity and food intake, as well as body weight lost were observed in rats and mice after administration of DBTL by oral, inhalation or through dermal applica tion. Eloody discharge which was prosent at the mouthes and nostrils were also seen. DBTL was mild toxic when applied by oral or through dermal application. The pyrolysates of DBTL sho wed a potential irritative effect on the respiratory tract. The elevation in activity of SGPT and concentratjon of SB were confirmed in rats after being treated DBTL at 1/10 LD50 for two weeks. Pathological examination revealed degeneration and local necrosis of liver cell.. Lesion of bile duct was also found as seen in necrosis of epithelial calls. Toxic effects on embryo, inclu ding distinct increase in the incidence of fetus death,were fonud in mece treated with DBTL at the doses of 1/50 LD50 or more during the sixth to the fifteenth day of gestation. No real teratoge nic effects, however,were confirmed. Spore-rec-assay of subtilis rec-M45 and rec + 17 showed that DBTL did not resulted in DNA damage in subtilis at 200-800 ug lerel.
出处
《卫生毒理学杂志》
CSCD
1989年第4期209-211,204,共4页
Journal of Health Toxicology
关键词
二月桂酸
二丁基锡
毒理学
Dibutyltin dilaurate
Acute toxicity
Subacute Toxicity
teratogenicity
Mutagenicity
