摘要
本研究用1mg/kg HgCl_2(SC)多次染毒,复制大鼠亚急性中毒模型,测定了汞在大鼠肾脏亚细胞中的分布。用Sephadex G-75凝胶层析分析汞与肾胞浆蛋白的结合状况和大鼠尿中汞的排泄形式,并对尿蛋白进行了SDS-PAGE电泳图谱分析。从生化毒理学角度探讨了汞引起肾脏慢性损伤时,汞与蛋白的结合状况和尿蛋白变化的规律及其床临诊断价值。
This paper reported subacute toxicity of Dihyd roxyglyxine ( DHG ) on the rats. The rats were divided into three groups, which were given DHG on entry by oral routes at the dosages 81. 14, 157.40, 808,04mg/kg, and a control group, The results showed that kidney was the main excret ory route of DHG and its metabolites which induced pathological change of urethremphraxis and renal pelvis stones. Edema of mitochondria of epithelial cell of renal tubules, incfease of lyso some in number and change of shape were found on electro-microscoric examination. DHG also decreased the activity of SDH.. Serum urea nitrogen increased to 9.35mnol/1. These results showed that the DHG causes obvious injury to kidney.
出处
《卫生毒理学杂志》
CSCD
1989年第3期159-161,136,共4页
Journal of Health Toxicology
关键词
汞中毒
肾
尿蛋白
层析
Dihydroxyglyxine
Renal toxicity
Urethremphraxis.
