摘要
对６６名铅作业工人作Ｐ３００测定，并与６４名健康成人作对照研究。铅作业工人分为现中毒组（１０名）、曾中毒组（２７名）、接触组（２９名），分别与健康人组作比较。结果显示：现中毒组的潜伏时显著长于健康人组；曾中毒组的波幅降低，与健康人组相比有极显著性差异，波幅差绝对值小于健康人组，亦有显著性差异，而接触组与健康人组相比，４项指标均无显著性差异。各铅作业工人的Ｐ３００与正常参考值比较，２名潜伏时、１名潜伏时差绝对值、１名波幅差绝对值超过正常参考值，２名波幅低于正常参考值，其他工人的４项指标均在正常范围。相关分析结果显示：铅作业工人的Ｐ３００潜伏时与血铅、尿铅均无相关。
300 was studied in 66 workers exposedto lead. The subjects were divided into
threegroups:currently-poisoned group (10 cases),previously-poisoned group(27 cases)
andunpoisoned group (29 cases).The result of theP300 measurement were separately
com-pared with the group of 64 healthy workersunexposed to occupational hazards,
Compairedwith the control group,the result showed the latency of p300 was prolonged in the
cur-rently-poisoned group (P<0.05),the ampli-tude wasdecreased in the
previously-poisonedgruuPP<0.001) and the absolute differencevale of amplitude between two
measure-ments was smaller in the previously-poisonedgroup (P<0.05).However,there was
nodifference in all 4 indices of the unpoisonedgroup compared with the control group.Inthe view
ofindividual exposed-worker in thestudy ,the latency in 2 cases,the absolutedifference value of
latency in 1 case and theabsolute ediffernce value of amplitude in1 case were exceeded and
the amplitude in2 cases was decreased ,compared with thereference valu The 4 indlces of rest
expcs d-workers were normal.Correlation analysisshowed no relation between the latency
ofP300 and blood lead and urine lead levels inthe exposed-workers. The result of this
studysuggested P300 .is significant to be used asan index of corebral function change in the
long-term lead exncsed workers. Yet, it willbe studied further whether it is usd as a diagnostic
index for subclinical poisoning .
出处
《中国工业医学杂志》
CAS
1994年第4期197-200,共4页
Chinese Journal of Industrial Medicine
关键词
P300
职业病
铅中毒
lead, event-related potential,ERP,P300,P3 ,cognitive
potential latency,amplitude
