摘要
对37例原发性高血压患者进行美托洛尔治疗前后心率、血压、总胆固醇、甘油三酯、糖耐量试验、胰岛素、24h尿钾、钠、钙、肌酐测定，结果表明：服用美托洛尔后心率、血压下降，尿钠排泄增加，糖负荷曲线略增高，胰岛素水平及胰岛素抗性（ISR）降低（P＜0．01），血脂无改变（P＞0．05）。提示美托洛尔对原发性高血压Ⅰ，Ⅱ期者，在改善血压、心率同时，不影响脂肪代谢，可增加尿纳排泄，对糖代谢、胰岛素及胰岛素抵抗影响较小。
This study was to determine the effect of 30week treatment of metoprolol on heart rate, blood pressurel cholesterol, triglyceride, blood sugar, glucose tolerance, insulin, kalium, sodium, calcium and urine (24 h) creatinine in 37 cases with essential hypertension. The results showed that heart rate and blood pressure were decreased, natruresis was increased , sugar tolerance curve was slightly deteriorated, insulin and insulin resistance were decreased (P < 0. 01 ), and blood-lipid was of not changed (P <0. 05 ).
关键词
美托洛尔
高血压
血脂
糖
代谢
hypertension
metoprolol
blood glucose
insulin
