摘要
目的:探讨初发糖尿病患者胰岛素早期分泌缺陷与血糖的关系,评价糖尿病患者的胰岛功能。方法:对初发未予降糖药治疗糖尿病病人53例,正常对照组9例,在进行常规口服葡萄糖耐量(OGTT)及胰岛素动态释放试验基础上加测口服葡萄糖后10min静脉血糖及血清胰岛素测定。按空腹血糖10mmol/L为标准将糖尿病患者分为低于10mmol/L(A)组(32例)及高于10mmol/L(B)组(21例)。结果:糖尿病患者空腹及120min血清胰岛素较对照组明显增高(P<0.01),而10min血清胰岛素明显低于对照组(P<0.05)。A组与B组比较,血清胰岛素A组除空腹低于B组外(P<0.05),其余10min、30min、60min、120min。均明显高于B组(P<0.01)。结论:用口服葡萄糖法测定早期(10min)胰岛素分泌的情况来了解2型糖尿病患者胰岛素早期分泌缺陷有一定意义,方法简便而且患者较容易接受。
Objective: Exploring the relation between the insulin earlier stage release defect and blood sugar in the non-treatment with medicine diabetics, To evaluate the diabetic's pancreatic island function. Methods: 53 no treatment with medicine diabetics and 9 normal controls were given routine oral glucose tolerance test(OGTT; and insulin dynamic realease test, after 10 minutes of taking oral glucose the blood sugar and serum insulin were measured added. According the fast blood sugar, the diabetics were divided into 2 groups, A group(32 patients;: the fast blood sugar were lower than 10 mmol/ L, B group (21 patients;:the fast blood sugar were higher than 10 mmol/L. Results: The fast blood sugar and serum insulin after taking oral glucose 120 minutes of diabetics were remarkably higher than those of normal controls(P<0.01;, the serum insulin after taking oral glucose 10 minutes of diabetics was markly lower than that of normal controls(P<0.05;.The fast serum insulin of A group was remarkably lower than that of B group(P<0.05;, but the serum insulins of after taking oral glucose 10, 30, 60 and 120 minutes of A group were remarkably higher than those of B group(P<0.01;. Conclusion: The measurement of the insulin earlier stage release(10 minutes after taking oral glucose; has a certain signification in understanding of earlier stage insulin secrete defect of type 2 diabetics. This method was convenient and easy accepted.
出处
《天津医科大学学报》
2005年第1期80-81,88,共3页
Journal of Tianjin Medical University
