摘要
我们采用了放免方法测定了30例正常人,30例脑肿瘤患者的血浆和脑脊液中cAMP、cGMP的含量。其中恶性肿瘤6例,良性肿瘤24例。其结果表明,脑肿瘤组血浆和脑脊液cAMP、cGMP的含量较正常对照组明显增高(P<0.005、P<0.001);恶性肿瘤组较良性肿瘤绍高;肿瘤组织的恶性度越高则血浆和脑脊液中cAMP/cGMP的比值就越低(P<0.01、P<0.05)。故我们认为血浆和脑脊液中cAMP、cGMP代谢水平的测定可以作为脑肿瘤病人的早期诊断、肿瘤监视和患者预后的一项参考指标。
The levets of cAMP and cGMP in plasns and CSF on 30 patients with cerebrotumours and normal peoples were measued by radioimmunoassay.Among 30 patients with cerebrotumour,6 ases were malignam,24 ases non-malignant. The results showed that levels of cAMP and cGMP in plasma aad CSF of the patients were considerably higher than that of controled group(P<0. 005,P<0. 001 ). and the malignant group were apparently higher than non malignant one(P<0. 05) both in plasma and CSF. The higher malignant degree of tumour tissue, the lower the cAMP/cGMP of plasma CSF(P<0, 05). We thought the measurement of cAMP and cGMP in plasma and CSF can be a reference of the early diagnosis,post - operation moni tor,therapy direction of cerebrotumour.
出处
《中风与神经疾病杂志》
CSCD
北大核心
1994年第2期84-86,共3页
Journal of Apoplexy and Nervous Diseases
