摘要
目的探讨GABRG2基因变异与内侧颞叶癫间疒的关系。方法运用RT-PCR方法测定内侧颞叶癫间疒致间疒灶和其他类型癫间疒病人手术切除脑组织内的GABRG2基因mRNA序列。结果全组共发现3处单核苷酸多态性,其中内侧颞叶癫间疒组245 G→A出现频率与对照组存在统计学差异。结论GABRG2基因突变极有可能在内侧颞叶癫间疒的发病中起重要作用。
Objective To study the relationship between the medial temporal epilepsy and mutations of GABRG2 gene. Methods Samples from the brain tissues confirmed as the epileptogenic areas were divided into two groups: medial temporal lobe epilepsy and other types epilesy as control. All the samples were detected by RT-PCR and sequencing. Results Three single nucleotide polymorphisms (SNPs) were found and statistically significant difference was observed for 245 G→A variant between the two groups. Conclusion Mutations of GABRG2 gene may play an important role in the occurrence of the medial temporal lobe epilepsy.
出处
《中国微侵袭神经外科杂志》
CAS
2005年第4期174-175,共2页
Chinese Journal of Minimally Invasive Neurosurgery
基金
国家自然科学基金资助项目(30130110)
关键词
癫痫
颞叶
点突变
逆转录聚合酶链反应
GABRG2基因
epilepsy, temporal lobe
point mutations
reverse transcriptase polymerase chain reaction
GABRG2 gene
